Synlett 2014; 25(07): 1014-1018
DOI: 10.1055/s-0033-1340872
letter
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of the Proposed Structure for Itralamide B

Xiaoji Wang*
a   School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. of China   Email: professorwxj@163.com
,
Chanshan Lv
a   School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. of China   Email: professorwxj@163.com
b   Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, 518055, P. R. of China   Email: xuzs@pkusz.edu.cn
,
Junyang Liu
b   Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, 518055, P. R. of China   Email: xuzs@pkusz.edu.cn
c   Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85222641912   Email: tao.ye@polyu.edu.hk
,
Linjun Tang
a   School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. of China   Email: professorwxj@163.com
,
Junmin Feng
a   School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. of China   Email: professorwxj@163.com
,
Shoubin Tang
b   Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, 518055, P. R. of China   Email: xuzs@pkusz.edu.cn
,
Zhuo Wang
c   Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85222641912   Email: tao.ye@polyu.edu.hk
,
Yuqing Liu
c   Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85222641912   Email: tao.ye@polyu.edu.hk
,
Yi Meng
b   Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, 518055, P. R. of China   Email: xuzs@pkusz.edu.cn
,
Tao Ye*
c   Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85222641912   Email: tao.ye@polyu.edu.hk
,
Zhengshuang Xu*
a   School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. of China   Email: professorwxj@163.com
b   Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, 518055, P. R. of China   Email: xuzs@pkusz.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 28 December 2013

Accepted after revision: 05 February 2014

Publication Date:
14 March 2014 (online)


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Abstract

A stereocontrolled total synthesis of the cyclodepsipeptide, itralamide B, has been achieved. Both R- and S-stereoisomers of the side chain were attached to the macrocyclic ring, however, the synthesized structure appears to be different from that of the marine natural product.

Supporting Information